Jamie Devitt, Paul Mullin and Andy Fleming could all miss Morecambe’s trip to Newport County on Saturday.
Both Devitt, back, and Mullin, calf, went off in the defeat to Dagenham and Redbridge on Sunday while Fleming’s partner has gone into labour.
Andy Wright could however come back into the squad after hernia surgery.
Shrimps boss Jim Bentley said: “Devitt’s got a bit of a bad back and had to come off early in Sunday’s game.
“It’s not a long term job but whether or not he’s right for this weekend we’ll have to see.
“Mullin’s going to calf injury and exactly the same as with Devitt we’ll just have to see what’s what.
“Andy Fleming’s off today (Thursday) because his missus has gone into labour.
“We’ve just taken a hit with one or two key players but we’ll see what happens today and tomorrow.
“We’re not bad at the moment with Wrighty coming back and I shouldn’t think Stewart Drummond will be long.”
Wright played 45 minutes for Morecambe’s Reserves in their 2-0 defeat to Wigan on Tuesday.
Bentley said: “Wrighty had a problem with his groin but after seeing a specialist or two it was decided he was going to have a double hernia.
“He’s responded really well and he’s fit and well after recovering quickly.
“It was good to see him back on the pitch and the 45 minutes in the reserves did him great.”
Joe McGee also returned from his cruciate knee ligament injury in the match as he continues to train with the club.
Bentley said: “Joe’s been out for so long and he’s not a player on contract but we’ve looked after him and done everything we can with regards to his rehab.
“He would have probably played a couple of weeks ago but with the games being called off he hasn’t been able to.
“He’s trained a lot, is fit and well and is chomping at the bit to get minutes under his belt and it was nice to see him back on the pitch as well.”
The Shrimps boss continues to also scour the loan market with an attacking midfielder the target.
Bentley said: “We’ve been knocked back by a couple.
“We know what we need it’s just about getting the right one.”