Buses were diverted down Morecambe Road after an accident on Torrisholme Road, Stagecoach reported.
Police said the accident at 11.23am involving a Citroen C3 and a Honda FR-V was at the junction of Torrisholme Road and Penrhyn Road.
One of the vehicles involved is believed to have hit a stationary car.
North West Ambulance Service were called to the scene and a person was taken to hospital for treatment for whiplash and bruising.
Penrhyn Road, which had been closed, was reopened at 12.26pm.