The A6 has been closed between Galgate and Lancaster after a collision involving a skip wagon and three cars.
The accident, close to junction 33 of the M6, occurred just before noon and police and paramedics attended the scene.
The skip wagon ended up on its side with the road blocked in both directions.
Three cars – a Mitsubishi L200, a Nissan Pathfinder and a Peugeot 206 – were all involved in the incident.
One man, who had been driving the wagon, was taken to the Royal Preston Hospital suffering a head injury.
Due to the accident, Stagecoach suspended all services operating between Lancaster and the university.